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PubMed · 10473962

Retinaldehyde alleviates rosacea.

M P Vienne·N Ochando·M T Borrel·Y Gall·C Lauze·P Dupuy
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Abstract

BACKGROUND: Anecdotal observations suggest that retinoic acid may be effective in mild rosacea. AIM: Our aim was to investigate, by an exploratory clinical and instrumental study, the effects of a topical formulation with the retinoic acid precursor retinaldehyde, in patients with vascular signs of facial rosacea. METHODS: Female patients were treated with a 0.05% retinaldehyde cream that was applied once daily for 6 months. Clinical assessments of persistent erythema and telangiectasia were performed every month, using a 4-point severity score (absent to severe). The clinical response for each parameter was defined as a decrease of at least 1 grade in the severity score. In addition, erythema was further evaluated by measurement of the a* parameter, using a spectrophotometer on lesional and nonlesional areas. RESULTS: A total of 23 women comprised the study population. At baseline, 10 patients had diffuse erythema, 3 patients had isolated telangiectasia and 10 patients had both. During retinaldehyde treatment, a clinical response was revealed in about 75% of the patients with erythema, after 5 months (p < 0.05). Similarly, isolated telangiectasia responded to retinaldehyde, although to a lesser extent and after a longer period of treatment (46% responders after 6 months, nonsignificant). Using the spectrophotometer, the a* parameter diminished in patients with erythema by about 15%, after 2 months of treatment (p = 0.001). CONCLUSION: This study indicates that retinaldehyde has beneficial effects on the vascular component of rosacea.

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Administration, TopicalAdultErythemaFacial DermatosesFemaleHumansMiddle AgedOintmentsRetinaldehydeRosaceaTelangiectasisClinical TrialJournal Article

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M P Vienne, N Ochando, M T Borrel, Y Gall, C Lauze, P Dupuy. 1999. Retinaldehyde alleviates rosacea.. https://doi.org/10.1159/000051380

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