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PubMed · 10474223

Boranophosphate nucleic acids--a versatile DNA backbone.

V Rait·D Sergueev·J Summers·K He·F Huang·B Krzyzanowska·B R Shaw
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Abstract

Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be synthesized enzymatically and form stable duplexes with DNA. Fully boronated, non-stereoregular oligothymidylates, synthesized chemically, form hybrids with poly(A) that have lower melting points than oligothymidylate:poly(A), yet they nevertheless can support the RNase H mediated cleavage of RNA.

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Boron CompoundsCrystallography, X-RayDNANucleic Acid ConformationNucleic AcidsOrganophosphorus CompoundsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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V Rait, D Sergueev, J Summers, K He, F Huang, B Krzyzanowska, B R Shaw. Boranophosphate nucleic acids--a versatile DNA backbone.. https://doi.org/10.1080/07328319908044721

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