Titin: a molecular control freak.

J Trinick; L Tskhovrebova

doi:10.1016/s0962-8924(99)01641-4

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PubMed · 10481174

Titin: a molecular control freak.

J Trinick·L Tskhovrebova

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Abstract

Recent studies of the giant protein titin have shed light on its roles in muscle assembly and elasticity and include the surprising findings described here. We now know that the titin kinase domain, which has long been a puzzle, has a novel regulation mechanism. A substrate, telethonin, has been identified that is located over one micron away from the kinase domain in mature muscle. Single-molecule studies have demonstrated the fascinating process of reversible mechanical unfolding of titin. Lastly, and most surprisingly, it has been claimed that titin controls assembly and elasticity in chromosomes.

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Animals Chromosomes Connectin Models, Molecular Muscle Contraction Muscle Proteins Muscles Protein Kinases Protein Structure, Secondary Sarcomeres Journal Article Research Support, Non-U.S. Gov't Review

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J Trinick, L Tskhovrebova. 1999. Titin: a molecular control freak.. https://doi.org/10.1016/s0962-8924(99)01641-4

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