Laminin-11.

J H Miner; B L Patton

doi:10.1016/s1357-2725(99)00030-8

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PubMed · 10481268

Laminin-11.

J H Miner·B L Patton

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Abstract

Laminins are a family of glycoproteins which are ubiquitous components of basement membranes and play key structural and functional roles. Eleven isoforms have been identified to date; each is an alpha beta gamma heterotrimer assembled from a repertoire of five alpha, three beta and two gamma chains. Studies of laminin-11 (alpha 5 beta 2 gamma 1) illustrate the unique expression patterns and distinct functions that can be displayed by laminin isoforms. Laminin-11 is found in the glomerular basement membrane in kidney, in the neuromuscular synaptic cleft in skeletal muscle and in other tissues such as placenta and lung. Mice lacking laminin-11 exhibit defective glomerular filtration and developmental defects in neuromuscular synapse formation, with Schwann cells invading the synaptic cleft. Consistent with these observations, both motoneurons and Schwann cells distinguish laminin-11 from other isoforms in vitro. These results suggest that laminin-11 is a structural component of the basement membrane which influences cell behavior in physiologically relevant ways. A greater understanding of laminin-11 assembly and basement membrane incorporation could provide a logical basis for therapy in merosin-deficient congenital muscular dystrophy.

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Animals Basement Membrane Laminin Muscular Dystrophies Neuromuscular Junction Protein Conformation Protein Isoforms Journal Article Review

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J H Miner, B L Patton. 1999. Laminin-11.. https://doi.org/10.1016/s1357-2725(99)00030-8

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