Expression and function of CD30 on T lymphocytes.

M Tarkowski

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PubMed · 10483869

Expression and function of CD30 on T lymphocytes.

M Tarkowski

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Abstract

T cell receptor, accessory molecules, cytokines are important regulatory factors that determine the development and function of T lymphocytes. Among them are also molecules belonging to superfamily of tumor necrosis factor receptor (TNFR) which beside CD30 include CD27, CD40, TNFR-I and -II, Fas (CD95), OX40, 4-1BB (CDw137), nerve growth factor receptor, lymphotoxin-beta receptor, Apo3/DR3/Ws1-1/lymphocyte associated receptor of death, DR4, DR5/TNF-related apoptosis-inducing ligand, osteoprotegerin, and TNFR-related 2. CD30 recognized originally on Reed-Sternberg cells of Hodgkin's lymphoma became of interest in studies of Th1 and Th2 cell differentiation. This paper shows recent findings regarding CD30 expression and its pleiotropic role in T cell function. It provides information about controversial role of CD30 as Th2 cell differentiation marker and gives concise insight into the function of this receptor as a signal transducing molecule.

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Animals Humans Ki-1 Antigen Receptors, Tumor Necrosis Factor T-Lymphocytes Journal Article Review

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M Tarkowski. 1999. Expression and function of CD30 on T lymphocytes.. https://pubmed.ncbi.nlm.nih.gov/10483869/

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