Mitochondrial DNA repair pathways.

D L Croteau; R H Stierum; V A Bohr

doi:10.1016/s0921-8777(99)00025-7

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Mitochondrial DNA repair pathways.

D L Croteau·R H Stierum·V A Bohr

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Abstract

DNA repair mechanisms are fairly well characterized for nuclear DNA while knowledge regarding the repair mechanisms operable in mitochondria is limited. Several lines of evidence suggest that mitochondria contain DNA repair mechanisms. DNA lesions are removed from mtDNA in cells exposed to various chemicals. Protein activities that process damaged DNA have been detected in mitochondria. As will be discussed, there is evidence for base excision repair (BER), direct damage reversal, mismatch repair, and recombinational repair mechanisms in mitochondria, while nucleotide excision repair (NER), as we know it from nuclear repair, is not present.

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Aging Alkylation Animals Cell Nucleus DNA Repair DNA, Mitochondrial Models, Biological Mutation Oxidative Stress Rats Recombination, Genetic Uracil Journal Article Review

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D L Croteau, R H Stierum, V A Bohr. 1999-07-30. Mitochondrial DNA repair pathways.. https://doi.org/10.1016/s0921-8777(99)00025-7

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