Bacterial mechanosensitive channels: integrating physiology, structure and function.

P Blount; P C Moe

doi:10.1016/s0966-842x(99)01594-2

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PubMed · 10498951

Bacterial mechanosensitive channels: integrating physiology, structure and function.

P Blount·P C Moe

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Abstract

When confronted with hypo-osmotic stress, many bacterial species are able rapidly to adapt to the increase in cell turgor pressure by jettisoning cytoplasmic solutes into the medium through membrane-tension-gated channels. Physiological studies have confirmed the importance of these channels in osmoregulation. Mutagenesis of one of these channels, combined with structural information derived from X-ray crystallography, has given the first clues of how a mechanosensitive channel senses and responds to membrane tension.

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Bacteria Crystallography, X-Ray Electrophysiology Escherichia coli Proteins Ion Channel Gating Ion Channels Models, Molecular Protein Conformation Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

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P Blount, P C Moe. 1999. Bacterial mechanosensitive channels: integrating physiology, structure and function.. https://doi.org/10.1016/s0966-842x(99)01594-2

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