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PubMed · 10500302

RMPs: recombination/replication mediator proteins.

H T Beernink·S W Morrical
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Abstract

Enzymes for DNA replication and recombination need to gain access to single-stranded DNA (ssDNA) but ssDNA-binding proteins (SSBs) present an obstacle to the formation of enzyme-ssDNA replication and recombination complexes. A specialized class of SSBs, which we designate as recombination/replication mediator proteins (RMPs), promotes enzyme- ssDNA assembly by overcoming SSB inhibition. RMPs exhibit strong conservation of function across divergent species, and display species-specific interactions with SSB and enzymes to neutralize the SSB barrier to enzyme-ssDNA assembly.

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Bacteriophage T4DNA ReplicationDNA, Single-StrandedDNA-Binding ProteinsRecombination, GeneticJournal Article

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H T Beernink, S W Morrical. 1999. RMPs: recombination/replication mediator proteins.. https://doi.org/10.1016/s0968-0004(99)01451-6

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