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The algorithm for cross-evaluation (ACE) of biologically active compounds.

D Kantoci
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Abstract

A non-linear algorithm, ACE (Algorithm for Cross-Evaluation), was developed to correlate the activity of anti-cancer drugs against human cell lines. ACE evaluates the relationships among compounds and cell lines and displays the resulting clusters on a 3-D surface plot. This plot along with a frequency plot and rank graph provides clear information regarding the sensitivity of groups of cell lines to particular compounds. The program was tested on published anti-cancer data sets and found associations useful in the selection and design of chemotherapy drugs for pre-clinical trials. ACE may be applied to other situations where details of groupings and relationships need to be extracted from large sets of data.

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D Kantoci. 1999. The algorithm for cross-evaluation (ACE) of biologically active compounds.. https://doi.org/10.1016/s0024-3205(99)00366-5

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