Kin protein expression: laminar specificity during rat cerebral cortex development.

I Ros; J Angulo; S Araneda

doi:10.1016/s0304-3940(99)00642-4

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Kin protein expression: laminar specificity during rat cerebral cortex development.

I Ros·J Angulo·S Araneda

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Abstract

Kin is a mammalian nuclear protein involved in DNA recombination-repair and the regulation of gene expression. The present study explored the expression of the Kin nuclear protein during postnatal development of the rat cerebral cortex, using immunocytochemistry with anti-RecA antibodies. The immunostaining of the Kin protein preferentially occurs within layers IV-V and VIb of the cortex in early postnatal developing brain, whereas in the adult rat this expression is observed unequivocally in all cortical layers. 35S-isotopic in situ hybridization for Kin-17 mRNA confirmed this Kin protein expression pattern and demonstrated its transcription in cortical neurons. This gradual age-related expression during development may have functional implications in the maturation processes of the cortex.

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Aging Animals Animals, Newborn Cerebral Cortex DNA-Binding Proteins Immunohistochemistry In Situ Hybridization Nuclear Proteins RNA, Messenger Rats Rats, Sprague-Dawley Substrate Specificity Tissue Distribution Journal Article Research Support, Non-U.S. Gov't

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I Ros, J Angulo, S Araneda. 1999-10-01. Kin protein expression: laminar specificity during rat cerebral cortex development.. https://doi.org/10.1016/s0304-3940(99)00642-4

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