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PubMed · 10505770

Biologic therapy for lymphoma.

M Bendandi·D L Longo
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Abstract

Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% response rate in patients with follicular lymphoma, frequently works when given a second time, and is demonstrating what seems to be synergistic activity when combined with chemotherapy. Radioimmunoconjugates using iodine-131 and yttrium-90 as payload are producing responses in refractory and aggressive lymphomas. Vaccines and adoptive cellular therapies are also showing promising results in early phase clinical testing.

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Antibodies, MonoclonalCancer VaccinesHumansImmunotherapy, ActiveImmunotherapy, AdoptiveInterferonsLymphomaJournal ArticleReview

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M Bendandi, D L Longo. 1999. Biologic therapy for lymphoma.. https://doi.org/10.1097/00001622-199909000-00005

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