Engineering the mouse genome by site-specific recombination.

D Metzger; R Feil

doi:10.1016/s0958-1669(99)00012-9

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PubMed · 10508631

Engineering the mouse genome by site-specific recombination.

D Metzger·R Feil

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Abstract

Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.

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Animals Chromosomes Gene Silencing Genetic Engineering Genetic Vectors Genome Integrases Mice Mice, Transgenic Mutagenesis Mutagenesis, Site-Directed Recombination, Genetic Viral Proteins Viruses Journal Article Review

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D Metzger, R Feil. 1999. Engineering the mouse genome by site-specific recombination.. https://doi.org/10.1016/s0958-1669(99)00012-9

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