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PubMed · 10508651

Proteolysis and cell migration: creating a path?

G Murphy·J Gavrilovic
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Abstract

Both serine and metalloproteinases have been implicated in the complex integrated events underlying cell migration but no definitive single mechanism has emerged. Work over the past two years linking both membrane and soluble proteinases with integrins and other adhesion proteins and with intracellular signalling systems could herald the beginnings of a potential expansion of our understanding of the role and regulation of proteolysis in cell migration.

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AnimalsCell MovementEndopeptidasesEndothelium, VascularExtracellular MatrixExtracellular Matrix ProteinsFibrinolysinHumansKeratinocytesMetalloendopeptidasesMiceMice, KnockoutNeoplasm InvasivenessNeoplasm ProteinsOsteoclastsProteinsReceptors, Cell SurfaceReceptors, Urokinase Plasminogen ActivatorSerine EndopeptidasesUrokinase-Type Plasminogen ActivatorJournal ArticleResearch Support, Non-U.S. Gov'tReview

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G Murphy, J Gavrilovic. 1999. Proteolysis and cell migration: creating a path?. https://doi.org/10.1016/s0955-0674(99)00022-8

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