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PubMed · 10508658

Extracellular matrix remodelling and cellular differentiation.

C Streuli
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Abstract

The extracellular matrix is not merely a passive structure. In the past few years, it has emerged that the matrix is a dynamic action zone that functions to instruct cellular phenotype. Extracellular matrix proteins interact directly with cell surface receptors to initiate signal transduction pathways and to modulate those triggered by differentiation and growth factors. The extracellular matrix also controls the activity and presentation of a wide range of growth factors. Thus modulation of the extracellular matrix, by remodelling its structure and activity, has profound effects on its function and the consequent behaviour of cells residing on or within it.

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AnimalsCell DifferentiationDrosophila melanogasterEnzyme InductionExtracellular MatrixExtracellular Matrix ProteinsGene Expression RegulationGrowth SubstancesInsect ProteinsIntegrinsKeratinocytesMetalloendopeptidasesMiceMice, TransgenicModels, BiologicalReceptors, Cell SurfaceSerine EndopeptidasesSignal TransductionTranscription, GeneticWound HealingJournal ArticleResearch Support, Non-U.S. Gov'tReview

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C Streuli. 1999. Extracellular matrix remodelling and cellular differentiation.. https://doi.org/10.1016/s0955-0674(99)00026-5

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