Type II restriction endonucleases: structural, functional and evolutionary relationships.

R A Kovall; B W Matthews

doi:10.1016/s1367-5931(99)00012-5

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Type II restriction endonucleases: structural, functional and evolutionary relationships.

R A Kovall·B W Matthews

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Abstract

Type II restriction endonucleases are a paradigm for site-specific cleavage of DNA. Recent structural analyses, in particular in the presence of various divalent metals, have shed new insight into the mechanisms of catalysis. In addition, during this past year the crystal structure determinations of MutH, lambda-exonuclease and FokI have revealed that these proteins are also members of the same family.

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Animals Deoxyribonucleases, Type II Site-Specific Evolution, Molecular Humans Models, Molecular Protein Conformation Structure-Activity Relationship Journal Article Research Support, U.S. Gov't, P.H.S.Review

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R A Kovall, B W Matthews. 1999. Type II restriction endonucleases: structural, functional and evolutionary relationships.. https://doi.org/10.1016/s1367-5931(99)00012-5

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