Notch around the clock.

O Pourquié

doi:10.1016/s0959-437x(99)00011-8

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PubMed · 10508694

Notch around the clock.

O Pourquié

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Abstract

The establishment of a segmental pattern within the vertebrate body plan is achieved during embryogenesis by the somitogenesis process. Two molecular systems have been implicated in this phenomenon: a molecular clock linked to vertebrate segmentation and the Notch signalling pathway. Rhythmic expression of the Lunatic Fringe gene in the presomitic mesoderm has now provided a link between these two systems.

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Animals Basic Helix-Loop-Helix Proteins Glycosyltransferases Membrane Proteins Mesoderm Mice Proteins Receptor Protein-Tyrosine Kinases Receptors, Notch Signal Transduction Transcription Factors Xenopus Xenopus Proteins Journal Article Research Support, Non-U.S. Gov't Review

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O Pourquié. 1999. Notch around the clock.. https://doi.org/10.1016/s0959-437x(99)00011-8

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