C-type lectin-like domains.

K Drickamer

doi:10.1016/s0959-440x(99)00009-3

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PubMed · 10508765

C-type lectin-like domains.

K Drickamer

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Abstract

Carbohydrate-recognition domains of C-type (Ca2+-dependent) animal lectins serve as prototypes for an important family of protein modules. Only some domains in this family bind Ca2+ or sugars. A comparison of recent structures of C-type lectin-like domains reveals diversity in the modular fold, particularly in the region associated with Ca2+ and sugar binding. Some of this diversity reflects the changes that occur during normal physiological functioning of the domains. C-type lectin-like domains associate with each other through several different surfaces to form dimers and trimers, from which ligand-binding sites project in a variety of different orientations.

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Animals Binding Sites Biological Evolution Calcium Humans Lectins Macromolecular Substances Models, Molecular Protein Conformation Protein Folding Journal Article Research Support, Non-U.S. Gov't Review

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K Drickamer. 1999. C-type lectin-like domains.. https://doi.org/10.1016/s0959-440x(99)00009-3

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