New animal lectin structures.

J M Rini; Y D Lobsanov

doi:10.1016/s0959-440x(99)00008-1

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PubMed · 10508773

New animal lectin structures.

J M Rini·Y D Lobsanov

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Abstract

The past year has provided the X-ray crystal structures of both the N-terminal domain of sialoadhesin and the extracytoplasmic domain of the cation-dependent mannose 6-phosphate receptor. These structures represent the first examples from the I- and P-type lectin families and provide important insights into how these transmembrane-spanning receptors function. In addition, structures of galectin-7 and of the carbohydrate-recognition domain of galectin-3 have given evidence of a new galectin quaternary structure. Finally, the structure of tachylectin-2, the first example of a fivefold symmetric beta-propeller protein, sheds light on the role played by this lectin in horseshoe crab host defense.

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Animals Antigens, Differentiation Galectin 3 Galectins Humans Lectins Membrane Glycoproteins Models, Molecular Protein Conformation Protein Structure, Secondary Receptor, IGF Type 2 Receptors, Immunologic Sialic Acid Binding Ig-like Lectin 1 Journal Article Review

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J M Rini, Y D Lobsanov. 1999. New animal lectin structures.. https://doi.org/10.1016/s0959-440x(99)00008-1

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