Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.

T Kunnari; K Ylihonko; A Hautala; K D Klika; P Mäntsälä; J Hakala

doi:10.1016/s0960-894x(99)00439-4

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PubMed · 10509907

Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.

T Kunnari·K Ylihonko·A Hautala·K D Klika·P Mäntsälä·J Hakala

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Abstract

Compounds produced by the polyketide ketoreductase deficient Streptomyces mutants HO61 and P67 are described. The structures of the compounds indicate that ketoreductase activity is required for correct condensation of the polyketide chain in the biosynthesis of aromatic polyketides.

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Alcohol Oxidoreductases Bacterial Proteins Ethers, Cyclic Molecular Structure Mutagenesis Streptomyces Journal Article Research Support, Non-U.S. Gov't

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T Kunnari, K Ylihonko, A Hautala, K D Klika, P Mäntsälä, J Hakala. 1999-09-20. Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.. https://doi.org/10.1016/s0960-894x(99)00439-4

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