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Simple chromosome exchanges are not linear with dose.

A A Edwards·P A Hone·J E Moquet·D C Lloyd
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Abstract

PURPOSE: To check whether simple chromosome exchanges are linearly related to radiation dose. MATERIALS AND METHODS: Go-irradiated lymphocytes were cultured to produce metaphase preparations. Chromosomes 1 and 2 were painted different colours and the remaining chromosomes counterstained. Cells containing a colour junction involving both chromosomes 1 and 2 were scored fully, so that simple and complex rearrangements were distinguished. RESULTS: At doses of 2 Gy and below very few complex rearrangements were seen. About 90% of exchanges were simple. At these doses the linear component of the dose-effect curve accounts on average for only approximately 30% of the observed yield. CONCLUSIONS: There is a square-law dose component to the yield of simple exchanges in addition to the linear term.

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Cells, CulturedChromosome AberrationsChromosomes, HumanDose-Response Relationship, RadiationHumansLymphocytesMaleJournal ArticleResearch Support, Non-U.S. Gov't

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A A Edwards, P A Hone, J E Moquet, D C Lloyd. 1999. Simple chromosome exchanges are not linear with dose.. https://doi.org/10.1080/095530099139584

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