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Subjective versus objective memory change after temporal lobe epilepsy surgery.

S M Sawrie·R C Martin·R Kuzniecky·E Faught·R Morawetz·F Jamil·M Viikinsalo·F Gilliam
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Abstract

OBJECTIVE: To examine subjective versus objective memory change after anterior temporal lobectomy (ATL). METHODS: A prospective, controlled study. Controls included 39 unoperated patients with intractable temporal lobe epilepsy (TLE) who were administered a series of cognitive and health-related quality of life measures at baseline and at 12-month follow-up intervals. The surgery sample included 65 patients with intractable, focal TLE who had undergone either a right or left ATL. These patients were tested preoperatively and at 6-month follow-up intervals. Subjective and objective memory change was quantified using a newly developed methodology to control for practice effect and regression to the mean. RESULTS: Measures of subjective and objective memory change were not significantly related in the surgery sample. Prevalence of significant subjective memory decline 1 year after surgery ranged from 3 to 7%, whereas prevalence of significant objective memory decline ranged from 26 to 55%. Postoperative levels of emotional distress significantly predicted self-reported memory decline 1 year after ATL. Postoperative medication side effect and seizure outcome were also related significantly to subjective memory change in patients who had undergone left ATL. CONCLUSIONS: Subjective and objective memory change after temporal lobectomy are not related. Complaints of significant memory decline after ATL are infrequent and may serve as a marker for depression or other mood disorder rather than organically based memory decline.

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AdultEpilepsy, Temporal LobeFemaleHumansMaleMemoryMemory DisordersMiddle AgedNeuropsychological TestsPostoperative ComplicationsPostoperative PeriodPrevalenceTemporal LobeJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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S M Sawrie, R C Martin, R Kuzniecky, E Faught, R Morawetz, F Jamil, M Viikinsalo, F Gilliam. 1999-10-22. Subjective versus objective memory change after temporal lobe epilepsy surgery.. https://doi.org/10.1212/wnl.53.7.1511

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