Humoral response to herpes simplex virus is complement-dependent.

X J Da Costa; M A Brockman; E Alicot; M Ma; M B Fischer; X Zhou; D M Knipe; M C Carroll

doi:10.1073/pnas.96.22.12708

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Humoral response to herpes simplex virus is complement-dependent.

X J Da Costa·M A Brockman·E Alicot·M Ma·M B Fischer·X Zhou·D M Knipe·M C Carroll

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Abstract

The complement system represents a cascade of serum proteins, which provide a major effector function in innate immunity. Recent studies have revealed that complement links innate and adaptive immunity via complement receptors CD21/CD35 in that it enhances the B cell memory response to noninfectious protein antigens introduced i.v. To examine the importance of complement for immune responses to virus infection in a peripheral tissue, we compared the B cell memory response of mice deficient in complement C3, C4, or CD21/CD35 with wild-type controls. We found that the deficient mice failed to generate a normal memory response, which is characterized by a reduction in IgG antibody and germinal centers. Thus, complement is important not only in the effector function of innate immunity but also in the stimulation of memory B cell responses to viral-infected cell antigens in both blood and peripheral tissues.

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Animals Antibodies, Viral B-Lymphocytes Complement System Proteins Herpes Simplex Herpesvirus 1, Human Immunologic Memory Mice T-Lymphocytes beta-Galactosidase Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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X J Da Costa, M A Brockman, E Alicot, M Ma, M B Fischer, X Zhou, D M Knipe, M C Carroll. 1999-10-26. Humoral response to herpes simplex virus is complement-dependent.. https://doi.org/10.1073/pnas.96.22.12708

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