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PubMed · 10542412

The PH superfold: a structural scaffold for multiple functions.

N Blomberg·E Baraldi·M Nilges·M Saraste
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Abstract

Pleckstrin homology (PH) domains form a structurally conserved family that is associated with many regulatory pathways within the cell. Domains with a nearly identical fold are found in other families that share no sequence similarity, suggesting the existence of a stable PH superfold. The PH domains generally function as regulated membrane-binding modules that bind to inositol lipids and respond to upstream signals by targeting the host proteins to the correct cellular sites. The other domains with a similar fold, such as the phosphotyrosine binding domains, recognize protein ligands.

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Amino Acid MotifsAnimalsBlood ProteinsEnzyme ActivationLigandsPhosphatidylinositolsPhosphoproteinsProtein ConformationProtein FoldingProtein Structure, TertiarySequence Homology, Amino AcidStatic ElectricityStructure-Activity RelationshipJournal ArticleReview

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BibTeXRIS

N Blomberg, E Baraldi, M Nilges, M Saraste. 1999. The PH superfold: a structural scaffold for multiple functions.. https://doi.org/10.1016/s0968-0004(99)01472-3

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