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PubMed · 10544522

Beta-lactam antibiotics functionalized with gem-bisphosphonates.

M Hornyák·J F Hartmann·F J Sztaricskai·A Koncz·F Hernádi
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Abstract

Acylation of amoxycillin and cephalexin with acids III, V and VII, and with isocyanate VIII furnished the corresponding beta-lactam antibiotics (X and XIII-XV, respectively). The antibacterial activity of these new antibiotic analogues against Helicobacter pylori was found to be identical with those of amoxycillin, Augmentin, erythromycin and ciprofloxacin.

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AcylationAmoxicillinAnti-Bacterial AgentsCephalexinDrug DesignHelicobacter pyloriMicrobial Sensitivity TestsOrganophosphonatesStaphylococcus aureusJournal ArticleResearch Support, Non-U.S. Gov't

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M Hornyák, J F Hartmann, F J Sztaricskai, A Koncz, F Hernádi. 1999. Beta-lactam antibiotics functionalized with gem-bisphosphonates.. https://pubmed.ncbi.nlm.nih.gov/10544522/

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