PubMed Health⌕ Search

PubMed · 10570690

What is attention-deficit/hyperactivity disorder?

Abstract

ADHD is a highly prevalent condition with the core symptoms of functionally impairing limitations in sustained attention and impulsivity/overactivity. Other frequent symptoms include overemotionality or overreactivity, academic underachievement, low self-esteem, and interpersonal difficulties. The assessment for and diagnosis of ADHD are complicated by the lack of a specific test or marker for the disorder, the occurrence of symptoms along a continuum in the population, and its frequent association with other neurodevelopmental and psychiatric disorders. Due to the often pervasive effects of these symptoms and their chronicity, treatment generally must be multifaceted and prolonged. Neuropsychological studies suggest that individuals with ADHD may have their most salient difficulties in the areas of organizing, preparing, and inhibiting responses. Neurobiologic studies suggest that the circuitry involving frontal cortical-basal ganglia connections may be structurally or functionally different in individuals with ADHD, although the specificity of these findings has not been researched thoroughly. ADHD symptoms are highly, although not entirely, heritable. Many questions remain as to the specifics of etiology and best treatment practices.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M Mercugliano. 1999. What is attention-deficit/hyperactivity disorder?. https://doi.org/10.1016/s0031-3955(05)70157-7

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning.

This study investigated whether the glycaemic index (GI) of breakfast cereal differentially affects children's attention and memory. Using a balanced cross-over design, on two consecutive mornings 64 children aged 6-11 years were given a high GI cereal and a low GI cereal in a counterbalanced order. They performed a series of computerised tests of attention and memory, once prior to breakfast and three times following breakfast at hourly intervals. The results indicate that children's performance declines throughout the morning and that this decline can be significantly reduced following the intake of a low GI cereal as compared with a high GI cereal on measures of accuracy of attention (M=-6.742 and -13.510, respectively, p<0.05) and secondary memory (M=-30.675 and -47.183, respectively, p<0.05).

Attention↗

Inhibitory control test is a simple method to diagnose minimal hepatic encephalopathy and predict development of overt hepatic encephalopathy.

OBJECTIVES: To compare inhibitory control test (ICT), a simple/rapid test of attention, to a standard psychometric battery (SPT) to diagnose minimal hepatic encephalopathy (MHE) and predict development of overt hepatic encephalopathy (OHE) in cirrhotic patients. METHODS: Fifty nonalcoholic cirrhotics and 50 age/educational-status-matched controls were given ICT and SPT in the same sitting. Performance impaired beyond two standard deviations of controls was considered MHE in cirrhotics. ICT results (lure/target response and lures/person) were compared between controls and cirrhotics and within cirrhotics with/without MHE. Receiver-operating characteristic analysis was used to study ICT for MHE diagnosis. Twenty subjects were administered SPT and ICT twice to assess test-retest reliability. All cirrhotics were followed routinely for the development of OHE. RESULTS: Cirrhotics performed worse than controls on SPT and ICT. Using SPT, 39 cirrhotics had MHE. ICT was administered faster than SPT (15 vs 37 min). Cirrhotics with MHE had significantly higher lure (28%vs 3%) and lower target response (91%vs 96%) compared with those without MHE. Lure/person >5 had 90% sensitivity/specificity for MHE diagnosis. AUC for receiver-operating characteristic for lures alone was 95.8%. Lure and target responses were highly correlated (r= 0.9) between sessions showing high test-retest reliability. Five (10%) patients developed OHE on f/u of 26 +/- 10 months; all five had been diagnosed with MHE using ICT and SPT. None of the five patients with discordant results on SPT and ICT developed OHE. CONCLUSIONS: ICT has good sensitivity/specificity for MHE diagnosis, is reliable and is equivalent to SPT for predicting OHE development.

Attention↗