Molecular model of postsynaptic potential.

D M Dubois; E Schoffeniels

doi:10.1073/pnas.72.5.1749

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PubMed · 1057167

Molecular model of postsynaptic potential.

D M Dubois·E Schoffeniels

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Abstract

A molecular model of the excitatory postsynaptic membrane is given in terms of two biochemical cycles intimately associated: an acetylcholine cycle and a calcium cycle. The acetylcholine controls the Na ionophores while calcium ions control the tk ionophore. The two ionophores are spatially separated but interact in such a way that the variation in K conductance precedes that in Na conductance. Digital simulation shows that our model accounts quantitatively for both the evolution of excitatory postsynaptic potential and current in a variety of experimental conditions.

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Acetylcholine Acetylcholinesterase Action Potentials Animals Biological Transport Calcium Kinetics Mathematics Membrane Potentials Models, Biological Potassium Sodium Synaptic Membranes Time Factors Journal Article

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D M Dubois, E Schoffeniels. 1975. Molecular model of postsynaptic potential.. https://doi.org/10.1073/pnas.72.5.1749

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