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PubMed · 10577501

The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects.

S R McKercher·G W Henkel·R A Maki
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Abstract

PU.1 is a transcription factor shown to regulate the expression of many important genes in myeloid and B cells. At birth, mice homozygous for the disruption of the PU.1 gene have erythrocytes, megakaryocytes, and T cells, but no mature myeloid or B cells. Cells with an inability to develop to maturity were found in this mouse for B cells, neutrophils, eosinophils, mast cells, and monocytes. Rescue of early monocytic cells by transfection with the PU.1 gene results in renewed development to macrophages. These results demonstrate that PU.1 is an important regulator in the development of cells in the hematopoietic system.

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AnimalsCell DifferentiationCell LineageCells, CulturedHematopoietic Stem CellsMiceMonocytesProto-Oncogene ProteinsTrans-ActivatorsProto-Oncogene Protein Spi-1Journal ArticleReview

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S R McKercher, G W Henkel, R A Maki. 1999. The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects.. https://doi.org/10.1002/jlb.66.5.727

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