Biocatalytic combinatorial synthesis.

J L Krstenansky; Y Khmelnitsky

doi:10.1016/s0968-0896(99)00145-5

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PubMed · 10579520

Biocatalytic combinatorial synthesis.

J L Krstenansky·Y Khmelnitsky

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Abstract

Combinatorial biocatalysis, based on a principle of the combinatorial use of biosynthetic steps rather than the combinatorial use of reagents, offers a complementary approach to combinatorial chemistry, which, used individually or in connection with synthetic organic transformations, provides access to analogues not readily accessible by chemical synthetic means alone. The issues and strategies particular to this approach are discussed. Examples are given demonstrating these principles as well as the unique advantages of achieving chemo-, regio- and stereoselectivity under mild reaction conditions that biocatalytic methods offer.

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Acylation Benzopyrans Biochemistry Catalysis Enzymes Laccase Lipase Oxidoreductases Substrate Specificity Subtilisin Triazoles Journal Article

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J L Krstenansky, Y Khmelnitsky. 1999. Biocatalytic combinatorial synthesis.. https://doi.org/10.1016/s0968-0896(99)00145-5

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