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PubMed · 10597500

Meta-analysis by combining p-values: simulated linkage studies.

R Guerra·C J Etzel·D R Goldstein·S R Sain
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Abstract

Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were consistently found by pooling raw data. In the absence of further information, combining p-values can provide an overall, but limited, assessment of different linkage studies. However, meta-analysis would be better viewed as a preliminary step toward the goal of analyzing the pooled raw data.

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Genetic LinkageGenetic MarkersGenetic TestingGenomeHumansModels, GeneticModels, StatisticalMultivariate AnalysisJournal ArticleMeta-AnalysisResearch Support, U.S. Gov't, P.H.S.

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R Guerra, C J Etzel, D R Goldstein, S R Sain. 1999. Meta-analysis by combining p-values: simulated linkage studies.. https://doi.org/10.1002/gepi.1370170798

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