Lysozyme association with nucleic acids.

L K Steinrauf; D Shiuan; W J Yang; M Y Chiang

doi:10.1006/bbrc.1999.1804

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PubMed · 10600509

Lysozyme association with nucleic acids.

L K Steinrauf·D Shiuan·W J Yang·M Y Chiang

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Abstract

Lysozyme is well known for the ability to hydrolyze the cell wall of bacteria. Based on the similarity of structure between lysozyme and histones as seen from the results of X-ray crystal structure determinations, we have postulated that binding to nucleic acids may be another biological function of lysozyme. We have therefore begun a systematic study of the interactions of lysozyme and related molecules with nucleic acids, and present here a preliminary report. Binding to DNA and RNA has been demonstrated from gel electrophoresis, enzyme activity, and coprecipitation studies. We suggest that this function of lysozyme will provide an explanation why Lee-Huang et al. (1999) [Proc. Natl. Acad. Sci. USA 96, 2678-2681] were able to call lysozyme a "killer protein" against the AIDS virus, and may provide a new avenue of research on AIDS therapy.

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Animals Antiviral Agents Bacteriophage lambda Chickens DNA DNA-Binding Proteins Deoxyribonuclease HindIII Egg Proteins Electrophoresis, Polyacrylamide Gel Enzyme Inhibitors HIV-1 Muramidase Nucleic Acids Journal Article Research Support, Non-U.S. Gov't

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L K Steinrauf, D Shiuan, W J Yang, M Y Chiang. 1999-12-20. Lysozyme association with nucleic acids.. https://doi.org/10.1006/bbrc.1999.1804

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