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PubMed · 10600725

Selectin-carbohydrate interactions in shear flow.

M B Lawrence
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Abstract

Hydrodynamic shear creates mechanical stresses on selectin bonds, modulating affinity and kinetic parameters. Chemical modification of sialyl Lewis(x) increases the strength of L-selectin bonds without altering recognition, suggesting that mechanical and biorecognition characteristics are separable. L-selectin bond formation rates may be strongly influenced by sulfate orientation in sulfo sialyl Lewis(x).

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M B Lawrence. 1999. Selectin-carbohydrate interactions in shear flow.. https://doi.org/10.1016/s1367-5931(99)00023-x

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