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PubMed · 10602413

Leukemogenesis by CBF oncoproteins.

A D Friedman
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Abstract

The AML1 and CBFbeta subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFbeta-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.

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ApoptosisCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsHumansLeukemiaMDS1 and EVI1 Complex Locus ProteinNeoplasm ProteinsOncogene Proteins, FusionProteinsProto-Oncogene ProteinsProto-OncogenesRUNX1 Translocation Partner 1 ProteinTranscription Factor AP-2Transcription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

A D Friedman. 1999. Leukemogenesis by CBF oncoproteins.. https://doi.org/10.1038/sj.leu.2401590

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