Shaping the genome--restriction-modification systems as mobile genetic elements.

I Kobayashi; A Nobusato; N Kobayashi-Takahashi; I Uchiyama

doi:10.1016/s0959-437x(99)00026-x

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Shaping the genome--restriction-modification systems as mobile genetic elements.

I Kobayashi·A Nobusato·N Kobayashi-Takahashi·I Uchiyama

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Abstract

A restriction enzyme gene is often linked to a modification methylase gene the role of which is to protect a recognition site on DNA from breakage by the former. Loss of some restriction-modification gene complexes leads to cell death through restriction breakage in the genome. Their behavior as genomic parasites/symbionts may explain the distribution of restriction sites and clarify certain aspects of bacterial recombination repair and mutagenesis. A comparison of bacterial genomes supports the hypothesis that restriction-modification gene complexes are mobile elements involved in various genome rearrangements and evolution.

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Bacteria DNA Restriction Enzymes Evolution, Molecular Genes, Bacterial Genome, Bacterial Host-Parasite Interactions Interspersed Repetitive Sequences Mutagenesis Recombination, Genetic Journal Article Research Support, Non-U.S. Gov't Review

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I Kobayashi, A Nobusato, N Kobayashi-Takahashi, I Uchiyama. 1999. Shaping the genome--restriction-modification systems as mobile genetic elements.. https://doi.org/10.1016/s0959-437x(99)00026-x

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