Altered states: programmed proteolysis and the budding yeast cell cycle.

P Jorgensen; M Tyers

doi:10.1016/s1369-5274(99)00030-2

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Altered states: programmed proteolysis and the budding yeast cell cycle.

P Jorgensen·M Tyers

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Abstract

The recent identification of an essential RING-H2 finger protein in the SCF E3 ubiquitin ligase complex of budding yeast has uncovered a family of related E3 enzymes, including the other main cell cycle E3 complex, the anaphase promoting complex (APC). Recent insights into APC-dependent proteolysis include a novel protease activity that dissolves cohesion between sister chromatids at anaphase, and a crucial phosphatase, Cdc14, whose release from the nucleolus eliminates cyclin-dependent kinase activity and thereby drives exit from mitosis.

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Anaphase-Promoting Complex-Cyclosome Cell Cycle Fungal Proteins Gene Expression Regulation, Fungal Ligases Peptide Synthases SKP Cullin F-Box Protein Ligases Ubiquitin-Protein Ligase Complexes Ubiquitin-Protein Ligases Yeasts Journal Article Research Support, Non-U.S. Gov't Review

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P Jorgensen, M Tyers. 1999. Altered states: programmed proteolysis and the budding yeast cell cycle.. https://doi.org/10.1016/s1369-5274(99)00030-2

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