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PubMed · 10611495

White matter ischaemia.

M A Petty·J G Wettstein
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Abstract

Brain and spinal cord white matter are vulnerable to the effects of ischaemia. Reduction of the energy supply leads to a cascade of events including depolarization, influx of Na(+) and the subsequent reverse operation of the membrane protein the Na(+)/Ca(2+) exchanger which ultimately terminates in intracellular Ca(2+) overload and irreversible axonal injury. Various points along the white matter damage cascade could be specifically targeted as a potential means of inhibiting the development of axonal irreversible injury.

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AnimalsBrainBrain IschemiaHumansNerve Fibers, MyelinatedRatsJournal ArticleReview

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M A Petty, J G Wettstein. 1999. White matter ischaemia.. https://doi.org/10.1016/s0165-0173(99)00025-9

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