Mitotic regulators govern progress through steps in the centrosome duplication cycle.

S J Vidwans; M L Wong; P H O'Farrell

doi:10.1083/jcb.147.7.1371

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Mitotic regulators govern progress through steps in the centrosome duplication cycle.

S J Vidwans·M L Wong·P H O'Farrell

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Abstract

Centrosome duplication is marked by discrete changes in centriole structure that occur in lockstep with cell cycle transitions. We show that mitotic regulators govern steps in centriole replication in Drosophila embryos. Cdc25(string), the expression of which initiates mitosis, is required for completion of daughter centriole assembly. Cdc20(fizzy), which is required for the metaphase-anaphase transition, is required for timely disengagement of mother and daughter centrioles. Stabilization of mitotic cyclins, which prevents exit from mitosis, blocks assembly of new daughter centrioles. Common regulation of the nuclear and centrosome cycles by mitotic regulators may ensure precise duplication of the centrosome.

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Amino Acid Sequence Animals Cdc20 Proteins Cell Cycle Proteins Centrioles Centrosome Cyclins Drosophila Drosophila Proteins Mitosis Molecular Sequence Data Phosphoprotein Phosphatases Protein Tyrosine Phosphatases Saccharomyces cerevisiae Proteins cdc25 Phosphatases Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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S J Vidwans, M L Wong, P H O'Farrell. 1999-12-27. Mitotic regulators govern progress through steps in the centrosome duplication cycle.. https://doi.org/10.1083/jcb.147.7.1371

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