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PubMed · 1061817

Some substituted naphthazarins as potential anticancer agents.

K D Paull·R K Zee-Cheng·C C Cheng
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Abstract

Some 2,3-bis(substituted methyl)naphthazarins and related compounds were synthesized by the Diels-Alder reaction of benzoquinone and 2,3-dimethylbutadiene followed by oxidation and substitution reactions. These compounds were prepared as potential biological alkylating agents. Screening results indicated that 1,4-diacetyl-6,7-dimethyl-4a,5,8,8a-tetrahydronaphthalene and 5,8-bis(benzoyloxy)-2,3-dimethyl-1,4-naphthoquinone possessed borderline activity against leukemia P388 and that naphthazarin diacetate possessed confirmed cytotoxicity against the cell culture of human epidermoid carcinoma of the nasopharynx.

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AnimalsAntineoplastic AgentsCarcinoma 256, WalkerCarcinoma, Ehrlich TumorLeukemia L1210Leukemia, ExperimentalMiceNaphthoquinonesOsteosarcomaSarcoma 180Sarcoma, ExperimentalJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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K D Paull, R K Zee-Cheng, C C Cheng. 1976. Some substituted naphthazarins as potential anticancer agents.. https://doi.org/10.1021/jm00224a029

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