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PubMed · 10622643

Strain differentiation in microsporidia.

H Rinder·S Katzwinkel-Wladarsch·A Thomschke·T Löscher
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Abstract

Microsporidia are obligate intracellular, spore-forming protozoa and are regarded as newly emerging pathogens . Enterocytozoon spp. as well as Encephalitozoon spp. are recognized as major aetiological agents in chronic diarrhoea of immnunocompromised patients. The detection and differentiation of strains within microsporidial species is a prerequisite for the elucidation of their hitherto unknown reservoirs and their mode of transmission . In Enterocytozoon bieneusi, the most prevalent human-pathogenic microsporidium, 6 different genotypes of the internal transcribed spacer (ITS) of the rRNA gene are known so far, with 12 polymorphic sites . This pathogen has infrequently been detected in 2 animal hosts only, pigs and rhesus macaques, and only the genotype of the latter has also been found in a human patient, too. Encephalitozoon cuniculi has a wider confirmed spectrum of animal hosts, but only one polymorphic site is known in the ITS, differing in 3 different numbers of a tetranucleotide repeat. Therefore, further genomic targets may have to be characterized, too. Few data are available on strain differentiation in Encephalitozoon intestinalis and E. hellem.

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AnimalsGenotypeHumansMicrosporidaSpecies SpecificityJournal ArticleResearch Support, Non-U.S. Gov'tReview

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H Rinder, S Katzwinkel-Wladarsch, A Thomschke, T Löscher. 1998. Strain differentiation in microsporidia.. https://pubmed.ncbi.nlm.nih.gov/10622643/

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