Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.

D Ribatti; A Vacca; A Marzullo; B Nico; R Ria; L Roncali; F Dammacco

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PubMed · 10629073

Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.

D Ribatti·A Vacca·A Marzullo·B Nico·R Ria·L Roncali·F Dammacco

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Abstract

Node biopsies of 16 benign lymphadenopathies and 72 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for counts of microvessels, total metachromatic mast cells (MCs) and MCs expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in B-NHLs. When grouped according to the Working Formulation (WF) malignancy grades, they were significantly higher in low-grade B-NHLs vs. lymphadenopathies and intermediate-grade vs. low-grade tumors and there was a further increase in the high-grade tumors. A high correlation was demonstrated in all groups of tissues between microvessel counts and both total metachromatic and tryptase-reactive MCs. These results suggest that angiogenesis in B-NHLs increases with their progression, and that MCs cooperate in its induction via the tryptase contained in their secretory granules.

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Chymases Disease Progression Female Humans Lymphatic Diseases Lymphoma, B-Cell Male Mast Cells Middle Aged Neovascularization, Pathologic Serine Endopeptidases Tryptases Journal Article Research Support, Non-U.S. Gov't

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D Ribatti, A Vacca, A Marzullo, B Nico, R Ria, L Roncali, F Dammacco. 2000-01-15. Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.. https://pubmed.ncbi.nlm.nih.gov/10629073/

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