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PubMed · 10629530

Resin effects in solid phase S(n)Ar and S(n)2 macrocyclizations.

Y Feng·K Burgess
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Abstract

Seven different supports were compared in solid-phase S(N)Ar and S(N)2 macrocyclization reactions. Product purities were assayed for a relatively facile ring-closure process to give products 1 and 3. Some less-facile ring-closure reactions give the undesired dimeric macrocyclization by-products 2; some of these more-demanding ring closures were also examined. Finally, experiments were performed to gauge the rate of cyclizations on different resins, and some qualitative data were obtained for this.

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DimerizationHydrocarbons, CyclicIndicators and ReagentsMolecular StructurePolystyrenesResins, PlantComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Y Feng, K Burgess. 2000. Resin effects in solid phase S(n)Ar and S(n)2 macrocyclizations.. https://doi.org/10.1002/(sici)1097-0290(200024)71%3A1%3C3%3A%3Aaid-bit2%3E3.0.co%3B2-k

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