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PubMed · 10629536

Polymer-assisted solution-phase (PASP) library synthesis of alpha-ketoamides.

M S South·T A Dice·J J Parlow
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Abstract

A parallel solution-phase library synthesis of alpha-ketoamides is described. The two-step library synthesis is accomplished using polymer-assisted solution-phase (PASP) synthesis techniques. This high-yielding, multi-step sequence utilizes sequestering resins for the removal of reactants, reactant by-products, and tagged reagents. The first step of the library synthesis utilizes PASP resins to mediate the amide coupling of an alpha-hydroxy acid with an amine. The second step uses PASP resins for the periodinane oxidation of the alpha-hydroxy acid to an alpha-ketoamide leaving highly pure products after simple filtration and evaporation.

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M S South, T A Dice, J J Parlow. 2000. Polymer-assisted solution-phase (PASP) library synthesis of alpha-ketoamides.. https://doi.org/10.1002/(sici)1097-0290(200024)71%3A1%3C51%3A%3Aaid-bit8%3E3.0.co%3B2-o

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