PubMed · 10632951
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C N Burkhart, C G Burkhart. Before using ivermectin therapy for scabies.. https://doi.org/10.1046/j.1525-1470.1999.00124.x
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TDR's research programme was initiated in 1976 at the same time that the pharmaceutical industry began to withdraw from the discovery and development of new drugs for tropical diseases. TDR collaborated with the industry right from the start, its prime objective initially being to ensure that candidate drugs already in the development pipeline, such as praziquantel, mefloquine, ivermectin, halofantrine and atovaquone/proguanil, were not shelved. It became clear during the 1980s that once candidate drugs in these existing pipelines had been processed, that would be it. TDR therefore developed a number of other ways for collaboration, including testing compounds already in development in companies for other therapeutic areas. One candidate identified in this way was an oral formulation of miltefosine, in development in Asta Medica for an antitumour indication. A joint Asta Medica (later Zentaris)/TDR development project was agreed, and despite its fair share of traumas during the development process, miltefosine is now registered for the treatment of visceral leishmaniasis in India, Germany and Colombia. This example of a successful TDR/pharmaceutical industry collaboration lives on in the various Public Private Partnerships such as the new Medicines for Malaria Venture that TDR helped to spawn.
A high performance thin-layer chromatography (HPTLC) method combined with densitometry for determination of phenothiazine derivatives is described. Quantitation was performed in reflectance mode by using a computer-controlled densitometer Desaga CD 60. Established calibration curve (r > 0.999), precision (RDS values: 0.95-2.53%), detection limits as well as recovery values (101.1-102.8%) were found to be satisfactory. The presented method is rapid, precise and sensitive, and may be alternative to traditionally used HPLC. The method has been successfully applied in the analysis of pharmaceutical formulations.