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PubMed · 10633044

A light-inactivated antibiotic.

W Lee·Z H Li·S Vakulenko·S Mobashery
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Abstract

Sodium 7beta-[(R)-2-(N(b)()-o-nitrobenzyloxycarbonyl)hydrazino-3-pheny lpropa namido]cephalosporanate (1) is described as a new type of beta-lactam antibiotic, which undergoes light-induced destruction of its beta-lactam moiety and hence becomes biologically inactive. This type of antibiotic holds the promise of self-destruction over a number of hours of exposure to light, so that it would not allow selection of resistance in the environment.

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BacteriaCarbamatesCephalosporinsLightMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsPhotochemistryJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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W Lee, Z H Li, S Vakulenko, S Mobashery. 2000-01-13. A light-inactivated antibiotic.. https://doi.org/10.1021/jm980648a

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