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PubMed · 10636028

Chess games: a model for RNA based computation.

A R Cukras·D Faulhammer·R J Lipton·L F Landweber
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Abstract

Here we develop the theory of RNA computing and a method for solving the 'knight problem' as an instance of a satisfiability (SAT) problem. Using only biological molecules and enzymes as tools, we developed an algorithm for solving the knight problem (3 x 3 chess board) using a 10-bit combinatorial pool and sequential RNase H digestions. The results of preliminary experiments presented here reveal that the protocol recovers far more correct solutions than expected at random, but the persistence of errors still presents the greatest challenge.

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AnimalsComputational BiologyComputer SimulationHumansModels, MolecularRNATranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov't

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A R Cukras, D Faulhammer, R J Lipton, L F Landweber. 1999. Chess games: a model for RNA based computation.. https://doi.org/10.1016/s0303-2647(99)00030-1

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