How does Mycobacterium leprae target the peripheral nervous system?

A Rambukkana

doi:10.1016/s0966-842x(99)01647-9

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How does Mycobacterium leprae target the peripheral nervous system?

A Rambukkana

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Abstract

Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.

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Cytoskeletal Proteins Dystroglycans Humans Laminin Leprosy Membrane Glycoproteins Mycobacterium leprae Myelin Sheath Peripheral Nerves Peripheral Nervous System Diseases Protein Isoforms Protein Structure, Tertiary Schwann Cells Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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A Rambukkana. 2000. How does Mycobacterium leprae target the peripheral nervous system?. https://doi.org/10.1016/s0966-842x(99)01647-9

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