Scaffolding and protein interactions in MAP kinase modules.

M Karandikar; M H Cobb

doi:10.1054/ceca.1999.0074

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PubMed · 10643560

Scaffolding and protein interactions in MAP kinase modules.

M Karandikar·M H Cobb

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Abstract

MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. They are activated within protein kinase cascades consisting of at least three kinases acting in series. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MAP kinase module, is organized on scaffolds with a variety of forms and functions. This review discusses similarities and differences in scaffolding proteins and mechanisms in yeast, flies, worms and mammals.

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Animals MAP Kinase Kinase Kinases MAP Kinase Signaling System Mitogen-Activated Protein Kinases Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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M Karandikar, M H Cobb. 1999. Scaffolding and protein interactions in MAP kinase modules.. https://doi.org/10.1054/ceca.1999.0074

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