Multiple comparisons in carcinogenesis study with right-censored survival data.

Y I Chen

doi:10.1002/(sici)1097-0258(20000215)19:3<353::aid-sim333>3.0.co;2-b

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Multiple comparisons in carcinogenesis study with right-censored survival data.

Y I Chen

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Abstract

This paper considers the practical problem in animal carcinogenesis experiments where several treatment groups are compared with a control group in a one-way layout and the observed survival data are subject to random right-censorship. Proposed herein are multiple testing procedures based on two-sample weighted logrank statistics, each comparing an individual treatment with the control, for determining which treatments are more effective than the control. The associated p-value of claiming a certain treatment is more effective than the control is also discussed. A test-based confidence set for the scale changes between each treatment and the control is then obtained. The comparative results of a Monte Carlo error rate and power study for small sample sizes are presented. Finally, a numerical example involving renal carcinoma in mice demonstrates the feasibility of the proposed multiple testing procedures and test-based confidence set.

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Animals Confidence Intervals Disease Models, Animal Interleukin-12 Interleukin-2 Kidney Neoplasms Mice Models, Statistical Monte Carlo Method Proportional Hazards Models Survival Analysis Comparative Study Journal Article Research Support, Non-U.S. Gov't

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Y I Chen. 2000-02-15. Multiple comparisons in carcinogenesis study with right-censored survival data.. https://doi.org/10.1002/(sici)1097-0258(20000215)19%3A3%3C353%3A%3Aaid-sim333%3E3.0.co%3B2-b

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