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PubMed · 10652468

The third function of the thymus.

B Seddon·D Mason
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Abstract

Nonresponsiveness of mammalian T cells to self-antigens is not totally accounted for in terms of clonal deletion, T-cell anergy and T-cell ignorance: studies have shown that the T-cell repertoire of healthy individuals contains cells with the potential to cause autoimmune disease. This article describes a T-cell-mediated mechanism that prevents the realization of this potential and indicates how its failure can lead to the development of autoimmunity.

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AnimalsAutoimmunityCD4 AntigensCell DifferentiationReceptors, Interleukin-2T-LymphocytesThymus GlandJournal ArticleReview

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B Seddon, D Mason. 2000. The third function of the thymus.. https://doi.org/10.1016/s0167-5699(99)01559-5

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