Dosage compensation: making 1X equal 2X.

V H Meller

doi:10.1016/s0962-8924(99)01693-1

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PubMed · 10652515

Dosage compensation: making 1X equal 2X.

V H Meller

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Abstract

Animals that have XX females and XY or XO males have differing doses of X-linked genes in each sex. Overcoming this is the most immediate and vital aspect of sexual differentiation. A number of systems that accurately compensate for sex-chromosome dosage have evolved independently: silencing a single X chromosome in female mammals, downregulating both X chromosomes in hermaphrodite Caenorhabditis elegans and upregulating the X chromosome in male Drosophila all equalize X-linked gene expression. Each organism uses a largely non-overlapping set of molecules to achieve the same outcome: 1X = 2X.

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Animals Dosage Compensation, Genetic Female Genetic Linkage Humans Male X Chromosome Journal Article Research Support, U.S. Gov't, P.H.S.Review

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V H Meller. 2000. Dosage compensation: making 1X equal 2X.. https://doi.org/10.1016/s0962-8924(99)01693-1

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