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PubMed · 10655029

Evolutionary genomics: reading the bands.

L D Hurst·A Eyre-Walker
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Abstract

The human genome is not a uniform structure but, instead, is a mosaic of bands. Some of these bands can be seen by the eye. Stained with Giemsa and viewed under the microscope each human chromosome has a prototypical pattern of light and dark bands (G and R bands respectively). Other bands are not so easily viewed. The human genome is, for example, a mosaic of isochores, blocks of DNA within which the proportion of the bases G and C at silent sites (introns, third positions in codons, intergene spacer) is fairly uniform. Recent work by Matassi and colleagues(1) has revealed what might be a new and unexpected banding pattern. They have found that the genes which are close together on the chromosome have similar rates of evolution. BioEssays 22:105-107, 2000.

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Chromosome BandingChromosomes, HumanEvolution, MolecularGenetic LinkageGenome, HumanHumansTime FactorsJournal ArticleReview

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L D Hurst, A Eyre-Walker. 2000. Evolutionary genomics: reading the bands.. https://doi.org/10.1002/(sici)1521-1878(200002)22%3A2%3C105%3A%3Aaid-bies1%3E3.0.co%3B2-s

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Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes.

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